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“Zyrtec can cause drowsiness,” Dr. Brooks says. “While not as frequent as for older antihistamines like Benadryl, I still see drowsiness with Zyrtec quite a bit. In fact, pilots are not ...
The degree of sleepiness that occurs is generally less than with first-generation antihistamines because second-generation antihistamines are more selective for the H1 receptor. [7] [5] Compared to other second-generation antihistamines, cetirizine can cause drowsiness. [7]
Zyrtec might cause drowsiness for some people, Dr. Younus says. Claritin is non-drowsy, but he says some people don’t think it’s as effective as Zyrtec. Allegra is also non-drowsy, but some ...
The most common adverse effects noted for second-generation agents include drowsiness, fatigue, headache, nausea and dry mouth. [ 4 ] Continuous and/or cumulative use of anticholinergic medications, including first-generation antihistamines, is associated with higher risk for cognitive decline and dementia in older people.
The second paragraph says, "Compared to other second-generation anti-histamines, cetirizine can cause drowsiness." The second paragraph of Pharmacodynamics says, "Cetirizine crosses the blood–brain barrier only slightly, and for this reason, produces minimal sedation compared to many other antihistamines."
First-generation antihistamines can easily cross the blood-brain barrier into the central nervous system to reach the H-1 receptors within, often causing drowsiness. [7] Second-generation antihistamines selectively bind to the peripheral H-1 receptors outside the blood-brain barrier, therefore they are less likely to cause sedation.
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