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Topical atropine is used as a cycloplegic, to temporarily paralyze the accommodation reflex, and as a mydriatic, to dilate the pupils. [15] Atropine degrades slowly, typically wearing off in 7 to 14 days, so it is generally used as a therapeutic mydriatic, whereas tropicamide (a shorter-acting cholinergic antagonist) or phenylephrine (an α-adrenergic agonist) is preferred as an aid to ...
The antidote for belladonna poisoning is an anticholinesterase (such as physostigmine) or a cholinomimetic (such as pilocarpine), the same as for atropine. [52] Atropa bella-donna is also toxic to many domestic animals, causing narcosis and paralysis. [53] However, cattle and rabbits eat the plant seemingly without suffering harmful effects. [50]
All parts of all plants in this genus contain the tropane alkaloids scopolamine and atropine, which are extremely toxic; ingestion is often fatal. These plants are closely related to and were once grouped with members of the genus Datura, which contain the same deadly alkaloids. Effects of ingestion may include losing connection with reality ...
The toxic berry of Atropa belladonna which contains the tropane deliriants scopolamine, atropine, and hyoscyamine.. Deliriants are a subclass of hallucinogen.The term was coined in the early 1980s to distinguish these drugs from psychedelics such as LSD and dissociatives such as ketamine, due to their primary effect of causing delirium, as opposed to the more lucid (i.e. rational thought is ...
Atropine is the standard anticholinergic drug used to manage the symptoms of nerve agent poisoning. ... It was subsequently withdrawn, as it was too toxic for safe ...
Prevention efforts include banning very toxic types of organophosphates. [2] Among those who work with pesticides the use of protective clothing and showering before going home is also useful. [6] In those who have organophosphate poisoning the primary treatments are atropine, oximes such as pralidoxime, and diazepam.
An individual seed contains about 0.1 mg of atropine, and the approximate fatal dose for adult humans is >10 mg atropine or >2–4 mg scopolamine. [ 36 ] Datura intoxication typically produces delirium, hallucination, hyperthermia , tachycardia , bizarre behavior, urinary retention , and severe mydriasis , with resultant painful photophobia ...
Alkaloids can be toxic too (e.g. atropine, tubocurarine). [12] Although alkaloids act on a diversity of metabolic systems in humans and other animals, they almost uniformly evoke a bitter taste. [13] The boundary between alkaloids and other nitrogen-containing natural compounds is not clear-cut. [14]