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As the disease progresses, people with ALS develop shortness of breath when lying down, during physical activity or talking, and eventually at rest. [116] Other symptoms include poor concentration, poor memory, confusion, respiratory tract infections, and a weak cough. Respiratory failure is the most common cause of death in ALS. [5]
[4] [5] ALS has an oligogenic mode of inheritance, meaning that mutations in two or more genes are required to cause disease. [6] C9orf72 is the most common gene associated with ALS, causing 40% of familial cases of ALS, as well as a small percentage of sporadic cases; [7] it also causes about 25% of familial cases of frontotemporal dementia. [6]
While each motor neuron disease affects patients differently, they all cause movement-related symptoms, mainly muscle weakness. [6] Most of these diseases seem to occur randomly without known causes, but some forms are inherited. [2] Studies into these inherited forms have led to discoveries of various genes (e.g. SOD1) that are thought to be ...
Amyotrophic Lateral Sclerosis, Multiple Sclerosis Primary lateral sclerosis ( PLS ) is a very rare neuromuscular disease characterized by progressive muscle weakness in the voluntary muscles . PLS belongs to a group of disorders known as motor neuron diseases .
Researchers say a new blood test can identify biomarkers that may help diagnose three neurodegenerative diseases, including ALS, earlier than current diagnostic methods
A dog with degenerative myelopathy often stands with its legs close together and may not correct an unusual foot position due to a lack of conscious proprioception. Canine degenerative myelopathy, also known as chronic degenerative radiculomyelopathy, is an incurable, progressive disease of the canine spinal cord that is similar in many ways to amyotrophic lateral sclerosis (ALS).
In April, the U.S. Food and Drug Administration granted accelerated approval for Biogen's ALS drug based on data that showed it reduced the protein levels. Clene's ALS drug shows reduction in ...
Amyotrophic lateral sclerosis (ALS), commonly referred to Lou Gehrig's disease, is a rare neurodegenerative disorder characterized by the gradual loss of both upper motor neurons (UMNs) and lower motor neurons (LMNs). [41] Although initial symptoms may vary, most patients develop skeletal muscle weakness that progresses to involve the entire ...
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