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Ciprofloxacin is weakly bound to serum proteins (20–40%). It is an inhibitor of the drug-metabolizing enzyme cytochrome P450 1A2, which leads to the potential for clinically important drug interactions with drugs metabolized by that enzyme. [5] Ciprofloxacin is about 70% available when administered orally. [3]
In U.S. government diet and health surveys conducted from 2007 to 2010, 6,189 children ages 2–17 were assessed. For those classified as allergic to cow's milk, mean weight, height and body-mass index were significantly lower than for their non-allergic peers. This was not true for children with other food allergies.
Children affected by allergies in the developed world: [2] 1 in 13 have eczema; 1 in 8 have allergic rhinitis; 3-6% are affected by food allergy; Children in the United States under 18 years of age: [3] Percent with any allergy: 27.2%; Percent with seasonal allergy: 18.9%; Percent with eczema: 10.8%; Percent with food allergy: 5.8%
Fluoroquinolones have varying specificity for cytochrome P450, so may have interactions with drugs cleared by those enzymes; the order from most P450-inhibitory to least, is enoxacin > ciprofloxacin > norfloxacin > ofloxacin, levofloxacin, trovafloxacin, gatifloxacin, moxifloxacin. [50]
Food allergies affect up to 10% of the worldwide population, and they are currently more prevalent in children (~8%) than adults (~5) in western nations. [34] In several industrialized countries, food allergies affect up to 10% of children. [93] Children are most commonly allergic to cow's milk, chicken eggs, peanuts, and tree nuts. [21]
Immunotherapy with Hymenoptera venoms is effective at desensitizing 80–90% of adults and 98% of children against allergies to bees, wasps, hornets, yellowjackets, and fire ants. Oral immunotherapy may be effective at desensitizing some people to certain food including milk, eggs, nuts and peanuts; however, adverse effects are common. [3]
Allergy to cow's milk is the most common food allergy in infants and young children [11] but most outgrow the allergy in early childhood. Introducing baked cow's milk to allergic patients is associated with accelerated resolution of milk allergy. [28]
Other food allergies, affecting less than 1 person per 10,000 population, may be considered "rare". [42] The most common food allergy in the US population is a sensitivity to crustacea. [42] Although peanut allergies are notorious for their severity, peanut allergies are not the most common food allergy in adults or children. Severe or life ...