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The core concept behind fetal circulation is that fetal hemoglobin (HbF) [14] has a higher affinity for oxygen than does adult hemoglobin, which, together with the difference in partial pressure of oxygen, allows a diffusion of oxygen from the mother's circulatory system to the fetus.
When the baby is born, the lungs are needed for oxygen transfer and need high blood flow which is encouraged by low PVR. The failure of the circulatory system of the newborn to adapt to these changes by lowering PVR leads to persistent fetal circulation. [2] The newborn is therefore born with elevated PVR, which leads to pulmonary hypertension.
Fetal hemoglobin, or foetal haemoglobin (also hemoglobin F, HbF, or α 2 γ 2) is the main oxygen carrier protein in the human fetus. Hemoglobin F is found in fetal red blood cells , and is involved in transporting oxygen from the mother's bloodstream to organs and tissues in the fetus.
The "E" series of prostaglandins are responsible for maintaining the openness of the ductus arteriosus (by dilation of vascular smooth muscle) throughout the fetal period. [3] Prostaglandin E2 (PGE 2 ), produced by both the placenta and the DA itself, is the most potent of the E prostaglandins, but prostaglandin E1 (PGE 1 ) also has a role in ...
Umbilical cord compression can result from, for example, entanglement of the cord, [16] a knot in the cord, [16] or a nuchal cord, [16] (which is the wrapping of the umbilical cord around the fetal neck) [17] but these conditions do not always cause obstruction of fetal circulation. Velamentous cord insertion; Single umbilical artery; Umbilical ...
A study of 32 normal pregnancies showed that fetal heart motion was visible at a mean human chorionic gonadotropin (hCG) level of 10,000 UI/L (range 8650–12,200). [19] Obstetric ultrasonography can also use Doppler technique on key vessels such as the umbilical artery to detect abnormal flow.
Prenatal development (from Latin natalis 'relating to birth') involves the development of the embryo and of the fetus during a viviparous animal's gestation.Prenatal development starts with fertilization, in the germinal stage of embryonic development, and continues in fetal development until birth.
A fetus or foetus (/ ˈ f iː t ə s /; pl.: fetuses, foetuses, rarely feti or foeti) is the unborn mammalian offspring that develops from an embryo. [1] Following the embryonic stage, the fetal stage of development takes place.