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Inhibition of adult neurogenesis in the hippocampus has been shown to have various effects on learning and memory, conditioning, and investigative behaviors. Impaired fear conditioning has been seen in studies involving rats with a lack of adult neurogenesis in the hippocampus. [58]
The main function of the SGZ is to carry out hippocampal neurogenesis, the process by which new neurons are bred and functionally integrated into the granular cell layer of the dentate gyrus. Contrary to long-standing beliefs, neurogenesis in the SGZ occurs not only during prenatal development but throughout adult life in most mammals ...
In the human, adult neurogenesis has been shown to occur at low levels compared with development, and in only three regions of the brain: the adult subventricular zone (SVZ) of the lateral ventricles, the amygdala and the dentate gyrus of the hippocampus.
The hippocampal formation is located in the temporal ... The subgranular zone of the dentate gyrus is one of only two major sites of adult neurogenesis in the ...
However, the SVZ of the ventral telencephalon persists throughout life. The adult SVZ is composed of four distinct layers [5] of variable thickness and cell density as well as cellular composition. Along with the dentate gyrus of the hippocampus, the SVZ is one of two places where neurogenesis has been found to occur in the adult mammalian ...
Adult neurogenesis [ edit ] The olfactory bulb is, along with both the subventricular zone and the subgranular zone of the dentate gyrus of the hippocampus, one of only three structures in the brain observed to undergo continuing neurogenesis in adult mammals.
Adult neurogenesis is the process by which functional, mature neurons are produced from neural stem cells (NSCs) in the adult brain. In most mammals, including humans, it only occurs in the subgranular zone of the hippocampus , and in the olfactory bulb . [ 1 ]
Gadd45 facilitates hippocampal long-term potentiation and enhances persisting memory for motor performance, aversive conditioning, and spatial navigation. [21] Additionally, DNA methylation has been shown to be important for activity-dependent modulation of adult neurogenesis in the hippocampus, which is mediated by GADD45b.