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  2. Centella asiatica - Wikipedia

    en.wikipedia.org/wiki/Centella_asiatica

    C. asiatica has been shown to activate telomerase more than any other known compound yet discovered: 8.8-fold. This exceeds the activation by other known telomerase activators: oleanolic acid 5.9-fold, Astragalus extract 4.3-fold, TA-65 2.2-fold, and maslinic acid 2-fold.

  3. List of plants used in herbalism - Wikipedia

    en.wikipedia.org/wiki/List_of_plants_used_in...

    It is used frequently in herbal teas and other herbal remedies. [120] A tea from the leaves is used as a highly effective cough medicine. In the traditional Austrian medicine Plantago lanceolata leaves have been used internally (as syrup or tea) or externally (fresh leaves) for treatment of disorders of the respiratory tract, skin, insect bites ...

  4. Telomeres in the cell cycle - Wikipedia

    en.wikipedia.org/wiki/Telomeres_in_the_cell_cycle

    Two concerns with applying telomerase inhibitors in cancer treatment are that effective treatment requires continuous, long-term drug application and that off-target effects are common. [30] For example, the telomerase inhibitor imetelstat, first proposed in 2003, [31] [32] has been held up in clinical trials due to hematological toxicity. [30]

  5. Dyskerin - Wikipedia

    en.wikipedia.org/wiki/Dyskerin

    Dyskerin is essential for the activity of telomerase by accumulating telomerase RNA component (TERC). [8] This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA ...

  6. Telomeric repeat–containing RNA - Wikipedia

    en.wikipedia.org/wiki/Telomeric_repeat...

    TERRA-Telomerase Interaction at Long Telomeres. At cells with long telomeres, TERRA is proposed to act as a negative regulator of telomerase activity. This direct inhibitor function acts through base-pairing of the tandem repeats found throughout TERRA's 3'-end to the complementary RNA template region of telomerase. [6]

  7. Telomerase reverse transcriptase - Wikipedia

    en.wikipedia.org/wiki/Telomerase_reverse...

    Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component that serves as a template for the telomere repeat.

  8. Telomestatin - Wikipedia

    en.wikipedia.org/wiki/Telomestatin

    Telomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of in vitro cancer cells. [1] It was first isolated from the bacteria Streptomyces anulatus. [1] Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region.

  9. Shennong Bencaojing - Wikipedia

    en.wikipedia.org/wiki/Shennong_Bencaojing

    Shennong Bencaojing (also Classic of the Materia Medica or Shen-nong's Herbal Classics [1] and Shen-nung Pen-tsao Ching; Chinese: 神農本草經) is a Chinese book on agriculture and medicinal plants, traditionally attributed to Shennong. Researchers believe the text is a compilation of oral traditions, written between the first and second ...