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Paracetamol, [a] or acetaminophen, [b] is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. [13] [14] [15] It is a widely available over-the-counter drug sold under various brand names, including Tylenol and Panadol. Paracetamol relieves pain in both acute mild migraine and episodic tension headache.
Use of a timed serum paracetamol level plotted on the nomogram appears to be the best marker indicating the potential for liver injury. [20] A paracetamol level drawn in the first four hours after ingestion may underestimate the amount in the system because paracetamol may still be in the process of being absorbed from the gastrointestinal ...
Paracetamol (acetaminophen) class antipyretics, which have negligible anti-inflammatory activity. Apart from paracetamol itself, the medications in this class are mainly previously marketed drugs which were withdrawn owing to safety concerns, one example of this being phenacetin. A few other medications have antipyretic effects of varying strength.
According to the scientists, it has been assumed that paracetamol was a completely safe drug to use in patients with high blood pressure. According to the scientists, it has been assumed that ...
English: Simplified schematic of the key pathways of paracetamol metabolism in the human body. The first step in conversion of paracetamol to NAPQI has been omitted ...
When paracetamol is taken in large quantities, a minor metabolite called N-acetyl-p-benzoquinone imine accumulates within the body. It is normally conjugated by glutathione , but when taken in excess, the body's glutathione reserves are not sufficient to deactivate the toxic NAPQI.