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The synergy between trimethoprim and sulfamethoxazole was first described in the late 1960s. [25] [26] [27] Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately, because they inhibit successive steps in the folate synthesis pathway. They are given in a one-to-five ratio in their tablet ...
Sulfamethoxazole inhibits dihydropteroate synthase, an enzyme involved further upstream in the same pathway. [24] Trimethoprim and sulfamethoxazole are commonly used in combination due to possible synergistic effects, and reduced development of resistance. [24] This benefit has been questioned. [26] Tetrahydrofolate synthesis pathway
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Megaloblastic anaemia; Methaemoglobinaemia; Erythema multiforme; Low blood sugar; Hepatitis (liver swelling); Crystalluria (crystals in the urine); Urinary obstruction causing difficulty passing urine
Sulfamethoxazole is primarily renally excreted via glomerular filtration and tubular secretion. [8] About 20% of the sulfamethoxazole in urine is the unchanged drug, about 15–20% is the N-glucuronide conjugate, and about 50–70 % is the acetylated metabolite. [11] Sulfamethoxazole is also excreted in human milk. [8]
If you or someone you know is struggling with alcohol dependence, misuse or addiction, contact the Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 800-662 ...
Drink enough water to stay hydrated, but take small sips and avoid drinking so much that you feel overfull. If your nausea is severe or ongoing, try avoiding drinks during your meals and for 30 to ...
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