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Tobramycin/dexamethasone, sold under the brand name Tobradex, is a fixed-dose combination medication in the form of eye drops and eye ointment, marketed by Alcon. [1] [2] [3] The active ingredients are tobramycin (an antibiotic) and dexamethasone (a corticosteroid). [2] It is prescribed for the treatment of pink eye in combination with ...
Tobramycin is on the World Health Organization's List of Essential Medicines. [11] In 2022, tobramycin was the 281st most commonly prescribed medication in the United States, with more than 600,000 prescriptions. [12] Tobrex eye drops are a 0.3% tobramycin sterile ophthalmic solution produced by Alcon Pharmaceuticals.
When applied to the surface of the eye, side effects may include a brief period of blurry vision and discoloration of contact lenses of the soft type. [7] [3] When used by mouth or injection, side effects may include headache, nausea, and a change to the color of the skin for a brief period of time. [3] Allergic reactions may rarely occur. [3]
Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B 3). [2] Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth. [1] Areas of the skin exposed to friction and radiation are typically affected first. [1]
Common side effects include red eyes, dry eyes, change in color of the eyes, blurry vision, and cataracts. [ 5 ] [ 6 ] [ 4 ] Use during pregnancy or breastfeeding is generally not recommended. [ 1 ] [ 6 ] [ 4 ] It is a prostaglandin analog and works by increasing the outflow of aqueous fluid from the eyes.
Topical formulations may be used in burns or for infections of the outside of the eye. [6] It is often only used for two days until bacterial cultures determine what specific antibiotics the infection is sensitive to. [7] The dose required should be monitored by blood testing. [5] Gentamicin can cause inner ear problems and kidney problems. [5]