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Shiga-like toxin (SLT) is a historical term for similar or identical toxins produced by Escherichia coli. [3] The most common sources for Shiga toxin are the bacteria S. dysenteriae and some serotypes of Escherichia coli (shigatoxigenic or STEC), which include serotypes O157:H7 , and O104:H4 .
The verocytotoxin (shiga-like toxin) can directly damage renal and endothelial cells. Thrombocytopenia occurs as platelets are consumed by clotting. Hemolytic anemia results from intravascular fibrin deposition, increased fragility of red blood cells, and fragmentation. [6]
Escherichia coli O157:H7 is a serotype of the bacterial species Escherichia coli and is one of the Shiga-like toxin–producing types of E. coli.It is a cause of disease, typically foodborne illness, through consumption of contaminated and raw food, including raw milk and undercooked ground beef.
Toxic shock syndrome (TSS) is a condition caused by bacterial toxins. [1] Symptoms may include fever, rash, skin peeling, and low blood pressure. [1] There may also be symptoms related to the specific underlying infection such as mastitis, osteomyelitis, necrotising fasciitis, or pneumonia.
It is then transported to the endoplasmic reticulum where it is further cleaved, leaving the A1 subunit of Shiga toxin free. The A1 subunit of Shiga toxin inhibits the 28s subunit of the ribosomal rRNA, this leads to inhibited protein production by the ribosomes. [34] With the cell's protein synthesis inhibited by Shiga toxin, the cell is ...
While tetanus toxin is produced from Clostridium tetani, a spore forming bacteria found in soil, Tetanus is a paralytic disease that is global and commonly affects newborns as well as non-immunized individuals. Tetanus enters the body of organisms through wounds or skin breaks and can be found in manure, soil, and dust.
Severe skin, eye and mucosal pain and irritation; Skin erythema with large fluid blisters that heal slowly and may become infected; Tearing, conjunctivitis, corneal damage; Mild respiratory distress to marked airway damage; All blister agents currently known are denser than air, and are readily absorbed through the eyes, lungs, and skin.
Kiyoshi Shiga attended the Medical School of Tokyo Imperial University in 1896, after his high school studies. [1] It was at the university when he was introduced to Kitasato ShibasaburÅ, one of Robert Koch's successors, who was a world-famous Japanese scientist studying the bacteriology and immunology of deadly disease at the time. [1]