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Stress can cause depression and depression-like symptoms through monoaminergic changes in several key brain regions as well as suppression in hippocampal neurogenesis. [118] This leads to alteration in emotion and cognition related brain regions as well as HPA axis dysfunction.
Symptoms must also cause clinically significant distress in important areas of everyday life (e.g. social or occupational). [22] For a diagnosis of a major depressive episode, the patient must also not have a history of manic or hypomanic episodes and their symptoms cannot meet the criteria for a mixed episode .
"Depression with anxious distress" was added into the DSM-5 as a means to emphasize the common co-occurrence between depression or mania and anxiety, as well as the risk of suicide of depressed individuals with anxiety. Specifying in such a way can also help with the prognosis of those diagnosed with a depressive or bipolar disorder.
Depression affects around 14.8 million adults in the U.S. That?s around 7 percent of the entire population aged 18 and over.
The internalizing disorders, with high levels of negative affectivity, include depressive disorders, anxiety disorders, obsessive-compulsive and related disorders, trauma and stressor-related disorders, and dissociative disorders, [4] [5] bulimia, and anorexia come under this category, [1] as do dysthymia, and somatic disorders (in Huberty 2017) and posttraumatic stress disorder (in Huberty 2004).
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