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  2. Paroxetine - Wikipedia

    en.wikipedia.org/wiki/Paroxetine

    When taken orally, it achieves maximum concentration in about 6–10 hours [82] and reaches steady-state in 7–14 days. [93] Paroxetine exhibits significant interindividual variations in volume of distribution and clearance. [93] Less than 2% of an oral dose is excreted in urine unchanged. [93] Paroxetine is a mechanism-based inhibitor of ...

  3. Antidepressant discontinuation syndrome - Wikipedia

    en.wikipedia.org/wiki/Antidepressant...

    Occasionally symptoms can last up to one year. [3] They typically resolve within a day of restoring the medication. [20] Paroxetine and venlafaxine seem to be particularly difficult to discontinue, and prolonged withdrawal syndrome (post-acute-withdrawal syndrome, or PAWS) lasting over 18 months has been reported with paroxetine. [21] [22] [23]

  4. Study 329 - Wikipedia

    en.wikipedia.org/wiki/Study_329

    Of the 275, 93 were given paroxetine, 95 imipramine and 89 placebo. The paroxetine group were given 20 mg daily for four weeks, rising to 30 mg at week five and 40 mg at week six if the clinician thought it appropriate. [32] The last study visit was in May 1997, and the blind was broken in October. [33]

  5. Development and discovery of SSRI drugs - Wikipedia

    en.wikipedia.org/wiki/Development_and_discovery...

    Paroxetine (3S,4R)-3-[(2H-1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine [34] Paroxetine belongs to the phenylpiperidines. They contain a phenylpiperidine skeleton which consists of a piperidine bound to a phenyl group. [34] F The most potent 5-HT re-uptake blocker. It's the most potent blocker of muscarinic receptors among the SSRIs.

  6. Selective serotonin reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Selective_serotonin...

    Paroxetine may produce discontinuation-related symptoms at a greater rate than other SSRIs, though qualitatively similar effects have been reported for all SSRIs. [ 181 ] [ 182 ] Discontinuation effects appear to be less for fluoxetine, perhaps owing to its long half-life and the natural tapering effect associated with its slow clearance from ...

  7. Simply Pop: Coke steps into the prebiotic soda market with a ...

    www.aol.com/simply-pop-coke-steps-prebiotic...

    The new products, an extension of Coke's "Simply" line, do not have any added sugar and include 6 grams of prebiotic fiber "to support gut health," Vitamin C and Zinc to support immune function ...

  8. List of antidepressants - Wikipedia

    en.wikipedia.org/wiki/List_of_antidepressants

    This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.

  9. Dying To Be Free - The Huffington Post

    projects.huffingtonpost.com/dying-to-be-free...

    The last image we have of Patrick Cagey is of his first moments as a free man. He has just walked out of a 30-day drug treatment center in Georgetown, Kentucky, dressed in gym clothes and carrying a Nike duffel bag. The moment reminds his father of Patrick’s graduation from college, and he takes a picture of his son with his cell phone.