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According to the Crohn’s and Colitis Foundation, potential factors that may aggravate a Crohn’s flare-up are: Missing doses of prescription medication intended for Crohn’s treatment Taking ...
Maintenance of remission after surgery for Crohn's disease [12] A combination of azathioprine and infliximab treatment may be more effective than a single dose of infliximab to induce steroid-free remission for people with active Crohn's disease. [9] Azathioprine treatment may lead to rare but life-threatening side effects.
There was a prevailing view that Crohn's disease is a primary T cell autoimmune disorder; however, a newer theory hypothesizes that Crohn's results from an impaired innate immunity. [121] The later hypothesis describes impaired cytokine secretion by macrophages , which contributes to impaired innate immunity and leads to a sustained microbial ...
Crohn's patients have flares of their disease between periods of disease quiescence. Severe flares are usually treated with steroid medications to obtain remission, but steroids have many undesirable side effects, so some gastroenterologists are now advocating the use of infliximab as the first drug to try to get patients into remission. This ...
The anti-TNF-α monoclonal antibody infliximab is a major biological therapy for inflammatory bowel diseaseBiological therapy, the use of medications called biopharmaceuticals or biologics that are tailored to specifically target an immune or genetic mediator of disease, plays a major role in the treatment of inflammatory bowel disease. [1]
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