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Postherpetic neuralgia (PHN) is neuropathic pain that occurs due to damage to a peripheral nerve caused by the reactivation of the varicella zoster virus (herpes zoster, also known as shingles). PHN is defined as pain in a dermatomal distribution that lasts for at least 90 days after an outbreak of herpes zoster. [ 1 ]
On electron microscopy, nemaline bodies within the affected muscle fibers may be found. These bodies are sometimes crisply rod-shaped, but can also be irregular and punctate. The rods may be found alongside atrophic muscle fibers, and may be seen arising from the thickened Z-discs of the sarcolemmae. Affected fibers may be vacuolated or ...
In some people, shingles can reactivate presenting as zoster sine herpete: pain radiating along the path of a single spinal nerve (a dermatomal distribution), but without an accompanying rash. This condition may involve complications that affect several levels of the nervous system and cause many cranial neuropathies , polyneuritis , myelitis ...
The recent study also found that having had shingles carried a higher risk of subjective cognitive decline for men who carried the gene APOE4 — associated with cognitive impairment and dementia ...
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If you have a new or unexplained rash, here's what you should know as monkeypox cases rise in California.
The ankle joint marks the point of connection between the bones of the leg and those of the foot, and controls the raising and lowering of the foot. The ankle is often considered to comprise not only the ankle joint itself but also the structures surrounding it at the lower end of the leg and the beginning of the foot proper.
According to the U.S. Centers for Disease Control and Prevention, shingles affects a third of Americans, but Ramsay Hunt syndrome and encephalitis are far less common and can be severe.
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