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Doses greater than 40 000 IU (1000 μg) per day are generally required before high blood calcium occurs. [12] Normal doses, 800–2000 IU per day, are safe in pregnancy. [5] Cholecalciferol was first described in 1936. [13] It is on the World Health Organization's List of Essential Medicines. [14]
The Swedish National Food Agency recommends a daily intake of 10 μg (400 IU) of vitamin D 3 for children and adults up to 75 years, and 20 μg (800 IU) for adults 75 and older. [ 175 ] Non-government organisations in Europe have made their own recommendations.
Nature Made is an American dietary supplement and vitamin brand founded in 1971 by Barry Pressman and Henry Burdick. [ 1 ] [ 2 ] Nature Made began operating as a brand of Pharmavite as of this date. [ when? ] [ 3 ] [ better source needed ] Parent company Pharmavite was acquired by Otsuka Pharmaceutical in 1989.
Calcitriol is a hormone and the active form of vitamin D, normally made in the kidney. [8] [9] [10] It is also known as 1,25-dihydroxycholecalciferol.It binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [11]
Vitamin World, Inc. was founded in 1977 as a subsidiary of NBTY Inc, later the Nature's Bounty Company. [1] NBTY manufactured and sold vitamin and mineral supplement products under the "Vitamin World" label, sports nutrition products under their "Precision Engineered" label, and numerous National Brand label products at the stores.
Softgel capsules used for large amounts of vitamin E. Vitamin E is fat soluble, so dietary supplement products are usually in the form of the vitamin, esterified with acetic acid to generate tocopheryl acetate, and dissolved in vegetable oil in a softgel capsule. [3] For alpha-tocopherol, amounts range from 100 to 1000 IU per serving.
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