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Men with faults in their BRCA2 gene are at higher risk of aggressive prostate cancer.
Since men without a history of breast cancer who carry a mutation in a BRCA2 or BRCA1 gene have increased rates of developing prostate cancer, screening for prostate cancer in men with beast cancer who are 45 years or older and carry a BRCA2 gene mutation is strongly recommended and should be considered for men with a BRCA1 gene mutation
Women with deleterious mutations in either the BRCA1 or BRCA2 genes have a high risk of developing breast and/or ovarian cancer.Because different studies look at different populations, and because different types of mutations have somewhat different risks, the risk is best expressed as a range, rather than a single number.
Certain variations of the BRCA2 gene increase risks for breast cancer as part of a hereditary breast–ovarian cancer syndrome. Researchers have identified hundreds of mutations in the BRCA2 gene, many of which cause an increased risk of cancer. BRCA2 mutations are usually insertions or deletions of a small number of DNA base pairs in the gene.
Those groups include Black men, people with a family history of the cancer, and those with a genetic predisposition, such as having the BRCA gene, Dr. Lipshultz says.
In general, more and more people are becoming more aware of how genetics influence disease risk.
The likelihood that a woman may develop ovarian and breast cancer is increased by certain gene abnormalities. Male breast cancer and prostate cancer risk are both increased by BRCA2 gene mutations Men and women with BRCA2 gene mutations have a marginally increased chance of acquiring pancreatic cancer. (53)
Home genetic test kits from 23andMe may detect some important BRCA gene mutations that can increase your risk for breast cancer. Here's what to know before you test.