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Working together, biologists James Till and Ernest McCulloch made contributions to stem cell research by demonstrating the existence of multipotent stem cells in 1961. They helped lay the foundation for modern stem cell biology and regenerative medicine through their work while studying the effects of radiation on the bone marrow of mice at the Ontario Cancer Institute in Toronto.
Ernest Armstrong McCulloch OC OOnt FRS FRSC [1] (27 April 1926 [2] – 20 January 2011) [3] was a University of Toronto cellular biologist, best known for demonstrating – in a partnership with James Till – the existence of stem cells.
Subsequently, Till chose to work with Ernest McCulloch at the University of Toronto. Thus, the older physician's insight was combined with the younger physicist's rigorous and thorough nature. In the early 1960s, McCulloch and Till started a series of experiments that involved injecting bone marrow cells into irradiated mice. They observed that ...
Research into stem cells grew out of findings by Canadian biologists Ernest McCulloch, James Till and Andrew J. Becker at the University of Toronto and the Ontario Cancer Institute in the 1960s. [ 2 ] [ 3 ] As of 2016 [update] , the only established medical therapy using stem cells is hematopoietic stem cell transplantation , [ 4 ] first ...
James G. Fujimoto: Inventing optical coherence tomography. [10] David Huang: Eric A. Swanson: Special Achievement Piet Borst: A scientific career spanning 50 years, mentorship, and leadership [11] 2022 Basic Richard O. Hynes: For discoveries concerning the integrins – key mediators of cell–matrix and cell–cell adhesion in physiology and ...
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