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The term "homology" was first used in biology by the anatomist Richard Owen in 1843 when studying the similarities of vertebrate fins and limbs, defining it as the "same organ in different animals under every variety of form and function", [6] and contrasting it with the matching term "analogy" which he used to describe different structures ...
Homoplasy, in biology and phylogenetics, is the term used to describe a feature that has been gained or lost independently in separate lineages over the course of evolution. This is different from homology , which is the term used to characterize the similarity of features that can be parsimoniously explained by common ancestry . [ 1 ]
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a speciation event (orthologs), or a duplication event (paralogs), or else a horizontal (or lateral) gene ...
Convergent evolution is the independent evolution of similar features in species of different periods or epochs in time. Convergent evolution creates analogous structures that have similar form or function but were not present in the last common ancestor of those groups.
A protein superfamily is the largest grouping of proteins for which common ancestry can be inferred (see homology).Usually this common ancestry is inferred from structural alignment [1] and mechanistic similarity, even if no sequence similarity is evident. [2]
In modern day biology, the depth of understanding deep homology has evolved into focusing on the molecular and genetic mechanisms and functions rather than simple morphology. Cancer stem cells (CSCs) are a population of cells within a tumor that have the ability to self-renew and differentiate into different cell types, similar to normal stem ...
Serial homology is a special type of homology, defined by Owen as "representative or repetitive relation in the segments of the same organism." [ 1 ] Ernst Haeckel preferred the term "homotypy" for the same phenomenon.
Homology-directed repair (HDR) is a mechanism in cells to repair double-strand DNA lesions. [1] The most common form of HDR is homologous recombination . The HDR mechanism can only be used by the cell when there is a homologous piece of DNA present in the nucleus , mostly in G2 and S phase of the cell cycle .