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Macrophage polarization is a process by which macrophages adopt different functional programs in response to the signals from their microenvironment. This ability is connected to their multiple roles in the organism: they are powerful effector cells of the innate immune system, but also important in removal of cellular debris, embryonic development and tissue repair.
In adipose tissue, distinction between M1 and M2 macrophage polarization can be monitored by assessing the expression of selected markers. Macrophages displaying M1 phenotype have been characterized by expression of F4/80, CD11c and iNOS whereas macrophages displaying M2 phenotype have been characterized by expression of F4/80, CD301 and Arg1. [10]
A macrophage can be polarized into the classic M1 or M2 phenotype, and this phenomenon can be seen in cigarette consumption. [2] In this polarization scheme, lower M1 markers and higher M2 markers have been observed. [4] The reprogram of macrophage implies a dysregulated inflammation that can damage healthy lung cells.
M2 is the phenotype of resident tissue macrophages, and can be further elevated by IL-4. M2 macrophages produce high levels of IL-10, TGF-beta and low levels of IL-12. Tumor-associated macrophages are mainly of the M2 phenotype, and seem to actively promote tumor growth. [56]
M2 group can further be divided into sub-groups M2a, M2b, M2c, and M2d. [2] Typically the M2 cells have anti-inflammatory and regulatory properties and produce many different anti-inflammatory cytokines such as IL-4, IL-33, IL-10, IL-1RA, and TGF-β. [3] [4] M2 cells can also secrete angiogenic and chemotactic factors. [5]
Electric polarization of a given dielectric material sample is defined as the quotient of electric dipole moment (a vector quantity, expressed as coulombs*meters (C*m) in SI units) to volume (meters cubed). [1] [2] Polarization density is denoted mathematically by P; [2] in SI units, it is expressed in coulombs per square meter (C/m 2).
Polarization (antenna), the state of polarization (in the above sense) of electromagnetic waves transmitted by or received by a radio antenna; Dielectric polarization, charge separation in insulating materials: Polarization density, volume dielectric polarization; Dipolar polarization, orientation of permanent dipoles
M1 (classical activation) and M2 (alternative activation) designate the two extremes of macrophage polarization. M1-polarized Kupffer cells produce a large amount of pro-inflammatory cytokines like TNF-alpha. On the other hand, M2-polarized Kupffer cells produce a large quantity of anti-inflammatory mediators, for example, IL-10. [9] [4]