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A human chimera is a human with a subset of cells with a distinct genotype than other cells, that is, having genetic chimerism.In contrast, an individual where each cell contains genetic material from a human and an animal is called a human–animal hybrid, while an organism that contains a mixture of human and non-human cells would be a human-animal chimera.
Innate chimeras are formed from at least four parent cells (two fertilised eggs or early embryos fused together). Each population of cells keeps its own character and the resulting organism is a mixture of tissues. Cases of human chimeras have been documented. [20]
Neo-Hittite Chimera from Karkemish, at the Museum of Anatolian Civilizations. The Neo-Hittite Chimera from Carchemish, dated 850–750 BC, which is now housed in the Museum of Anatolian Civilizations, is believed to be a basis for the Greek legend. It differs, however, from the Greek version in that a winged body of a lioness also has a human ...
In molecular biology, and more importantly high-throughput DNA sequencing, a chimera is a single DNA sequence originating when multiple transcripts or DNA sequences get joined. Chimeras can be considered artifacts and be filtered out from the data during processing [ 1 ] to prevent spurious inferences of biological variation. [ 2 ]
Human [ edit ] In humans (and perhaps in all placental mammals ), the most common form is fetomaternal microchimerism (also known as fetal cell microchimerism or fetal chimerism ) whereby cells from a fetus pass through the placenta and establish cell lineages within the mother.
A human chimera, on the other hand, consists only of human cells, from different zygotes.) Examples of human–animal hybrids mainly include humanized mice that have been genetically modified by xenotransplantation of human genes. [2] Humanized mice are commonly used as small animal models in biological and medical research for human ...
Chimera, Chimaera, or Chimaira (Greek for "she-goat") originally referred to: Chimera (mythology) , a fire-breathing monster of ancient Lycia said to combine parts from multiple animals Mount Chimaera , a fire-spewing region of Lycia or Cilicia typically considered the inspiration for the myth
Human parts are shown in brown, and non-human parts in blue. The purpose of creating fusion proteins in drug development is to impart properties from each of the "parent" proteins to the resulting chimeric protein. Several chimeric protein drugs are currently available for medical use.