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Alcohol intoxication leads to negative health effects due to the recent drinking of large amount of ethanol (alcohol). [6] [20] When severe it may become a medical emergency. Some effects of alcohol intoxication, such as euphoria and lowered social inhibition, are central to alcohol's desirability. [21]
Alcohol is known to potentiate the insulin response of the human body to glucose, which, in essence, "instructs" the body to convert consumed carbohydrates into fat and to suppress carbohydrate and fat oxidation. [63] [64] Ethanol is directly processed in the liver to acetyl CoA, the same intermediate product as in glucose metabolism.
Ethanol, when used to treat or prevent methanol and/or ethylene glycol toxicity, competes with other alcohols for the alcohol dehydrogenase enzyme, lessening metabolism into toxic aldehyde and carboxylic acid derivatives, and reducing the more serious toxic effects of the glycols when crystallized in the kidneys.
The level of ethanol consumption that minimizes the risk of disease, injury, and death is subject to some controversy. [16] Several studies have found a J-shaped relationship between alcohol consumption and health, [17] [18] [2] [19] meaning that risk is minimized at a certain (non-zero) consumption level, and drinking below or above this level increases risk, with the risk level of drinking a ...
The degree of intoxication however, varies between and within various cultures that engage in this practice. A binge on alcohol can occur over hours, last up to several days, or in the event of extended abuse, even weeks. Due to the long term effects of alcohol abuse, binge drinking is considered to be a major public health issue. [67]
The causes of alcohol abuse are complex and multi-faceted. Alcohol abuse is related to economic and biological origins and is associated with adverse health consequences. [45] Peer pressure influences individuals to abuse alcohol; however, most of the influence of peers is due to inaccurate perceptions of the risks of alcohol abuse. [48]
Alcohol-related brain damage [1] [2] alters both the structure and function of the brain as a result of the direct neurotoxic effects of alcohol intoxication or acute alcohol withdrawal. Increased alcohol intake is associated with damage to brain regions including the frontal lobe , [ 3 ] limbic system , and cerebellum , [ 4 ] with widespread ...
Alcohol dependence is a previous (DSM-IV and ICD-10) psychiatric diagnosis in which an individual is physically or psychologically dependent upon alcohol (also chemically known as ethanol). In 2013, it was reclassified as alcohol use disorder in DSM-5 , [ 1 ] which combined alcohol dependence and alcohol abuse into this diagnosis.