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The term "interstitial cystitis" was coined by Dr. Alexander Skene in 1887 to describe the disease. [13] In 2002, the United States amended the Social Security Act to include interstitial cystitis as a disability. The first guideline for diagnosis and treatment of interstitial cystitis is released by a Japanese research team in 2009. [71]
In interstitial cystitis, pentosan polysulfate is believed to work by providing a protective coating to the damaged bladder wall. Pentosan polysulfate is similar in structure to the natural glycosaminoglycan coating of the inner lining of the bladder , and may replace or repair the lining, reducing its permeability .
Eosinophilic cystitis is a rare type of interstitial cystitis first reported in 1960 by Edwin Brown. [1] Eosinophilic cystitis has been linked to a number of etiological factors, including allergies , bladder tumors , trauma to the bladder, parasitic infections , and chemotherapy drugs , though the exact cause of the condition is still unknown.
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network has found that CPPS and bladder pain syndrome/interstitial cystitis (BPS/IC) are related conditions. [ 30 ] UCPPS is a term adopted by the network to encompass both IC/BPS and CP/CPPS, which are proposed as related based on their similar symptom profiles.
Uses of nitrofurantoin include the treatment of uncomplicated urinary tract infections (UTIs) and prophylaxis against UTIs in people prone to recurrent UTIs. [9] It is a first-line therapy for acute uncomplicated cystitis. [21] It is not recommended for empiric treatment of hospital-acquired UTIs. [21]
Women with recurrent simple UTIs are over 90% accurate in identifying new infections. [4] They may benefit from self-treatment upon occurrence of symptoms with medical follow-up only if the initial treatment fails. [4] The combination sulopenem etzadroxil/probenecid (Orlynvah) was approved for medical use in the United States in October 2024 ...