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Common foods containing phytoestrogens are soy protein, beans, oats, barley, rice, coffee, apples, carrots (see Food Sources section below for bigger list). Its name comes from the Greek phyto ("plant") and estrogen , the hormone which gives fertility to female mammals .
Xenoestrogens are xenohormones that mimic the effects of natural estrogen. When present in the body, xenoestrogens can bind with estrogen receptors in the brain, leading to a disruption in the gonadal endocrine system. Xenoestrogen exposure during different developmental periods can have differing effects on the reproductive system.
Mycoestrogens mimic natural estrogen in the body by acting as estrogen receptor (ER) ligands. [8] Mycoestrogens have been identified as endocrine disruptors due to their high binding affinity for ERα and ERβ, exceeding that of well known antagonists such as bisphenol A and DDT. [10]
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Genistein was found to increase the rate of proliferation of estrogen-dependent breast cancer when not cotreated with an estrogen antagonist. [ 51 ] [ 52 ] [ 53 ] It was also found to decrease efficiency of tamoxifen and letrozole - drugs commonly used in breast cancer therapy.
A comparison of the structures of the natural estrogen hormone estradiol (left) and one of the nonyl-phenols (right), a xenoestrogen endocrine disruptor. Endocrine disruptors, sometimes also referred to as hormonally active agents, [1] endocrine disrupting chemicals, [2] or endocrine disrupting compounds [3] are chemicals that can interfere with endocrine (or hormonal) systems. [4]