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In addition to other formulations, ciclopirox is used in lacquers for topical treatment of onychomycosis (fungal infections of the nails). A meta-analysis of the six trials of nail infections available in 2009 concluded that they provided evidence that topical ciclopirox had poor cure rates, and that amorolfine might be substantially more effective, but more research was required.
But the truth is that toenail fungus or onychomycosis, to use the medical term, is incredibly common and can happen to anyone. In fact, 1 in 10 people are affected , and for those over 70, this ...
It is used to treat onychomycosis (fungal infection of the toe- and fingernails). Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications was shown in two decades-old studies to be between 60% and 71% effective in treating toenail onychomycosis; complete cure rates three months after stopping treatment (after six months of ...
[30] [31] [32] Some topical treatments need to be applied daily for prolonged periods (at least one year). [31] Topical amorolfine is applied weekly. [33] Efinaconazole, a topical azole antifungal, led to cure rates two or three times better than the next-best topical treatment, ciclopirox. [34] In trials, about 17% of people were cured using ...
Efinaconazole, sold under the brand name Jublia among others, is a triazole antifungal medication. It is approved for use in the United States, Canada, and Japan as a 10% topical solution for the treatment of onychomycosis (fungal infection of the nail). [3] [4] Efinaconazole acts as a 14α-demethylase inhibitor. [5] [2]
It takes about 25 years to develop a new antifungal drug, and a similarly long time to create a new fungicide, Van Rhijn said. Scientists have so far identified only a handful of viable molecular ...