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UCPs contain the three homologous protein domains of MACPs. Although it was originally thought to play a role in non-shivering thermogenesis, obesity, diabetes and atherosclerosis, it now appears that the main function of UCP2 is the control of mitochondria-derived reactive oxygen species. [8] Chromosomal order is 5'-UCP3-UCP2-3'. [9]
Structure of the human uncoupling protein UCP1. An uncoupling protein (UCP) is a mitochondrial inner membrane protein that is a regulated proton channel or transporter.An uncoupling protein is thus capable of dissipating the proton gradient generated by NADH-powered pumping of protons from the mitochondrial matrix to the mitochondrial intermembrane space.
22227 Ensembl ENSG00000109424 ENSMUSG00000031710 UniProt P25874 P12242 RefSeq (mRNA) NM_021833 NM_009463 RefSeq (protein) NP_068605 NP_033489 Location (UCSC) Chr 4: 140.56 – 140.57 Mb Chr 8: 84.02 – 84.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thermogenin (called uncoupling protein by its discoverers and now known as uncoupling protein 1, or UCP1) is a mitochondrial ...
7352 22229 Ensembl ENSG00000175564 ENSMUSG00000032942 UniProt P55916 P56501 RefSeq (mRNA) NM_022803 NM_003356 NM_009464 RefSeq (protein) NP_003347 NP_073714 NP_033490 Location (UCSC) Chr 11: 74 – 74.01 Mb Chr 7: 100.12 – 100.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitochondrial uncoupling protein 3 is a protein that in humans is encoded by the UCP3 gene. The gene is ...
In the damaged area of the brain after a brain injury, UP2 expression rises. In the brain, UCP2's ultimate role is in neuronal plasticity and neuronal survival. Specifically, in cerebral ischemia, studies suggest UCP2 regulates ROS production, neuroinflammation, mitochondrial potential, energy balance, neuroendocrine function, and cell death.
Genipin is a chemical compound found in Genipa americana fruit extract. It is an aglycone derived from an iridoid glycoside called geniposide which is also present in fruit of Gardenia jasminoides.
Names of individual SLC members have the following format: [4] where: SLC is the root name (SoLute Carrier)n = an integer representing a family (e.g., 1-52) X = a single letter (A, B, C, ...) denoting a subfamily
Barbara Cannon is a British-Swedish biochemist, physiologist and an academic.She is an emeritus professor at Stockholm University [1] as well as the chairman of the scientific advisory board at The Helmholtz Centre.