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Hypotonia is a state of low muscle tone [1] (the amount of tension or resistance to stretch in a muscle), often involving reduced muscle strength. Hypotonia is not a specific medical disorder, but a potential manifestation of many different diseases and disorders that affect motor nerve control by the brain or muscle strength.
Hypotonia can present clinically as muscle flaccidity, where the limbs appear floppy, stretch reflex responses are decreased, and the limb's resistance to passive movement is also decreased. [1] Hypertonia is seen in upper motor neuron diseases like lesions in pyramidal tract and extrapyramidal tract.
Symptoms associated with central nervous systems disorders are classified into positive and negative categories. Positive symptoms include those that increase muscle activity through hyper-excitability of the stretch reflex (i.e., rigidity and spasticity) where negative symptoms include those of insufficient muscle activity (i.e. weakness) and reduced motor function. [5]
Signs and symptoms of mitochondrial trifunctional protein deficiency that may begin after infancy include hypotonia, muscle pain, a breakdown of muscle tissue, and a loss of sensation in the extremities called peripheral neuropathy. Some who have MTP deficiency show a progressive course associated with myopathy, and recurrent rhabdomyolysis.
altered muscle tone (hypotonia or hypertonia) – a decrease or increase in the baseline level of muscle activity; decreased endurance; exaggerated deep tendon reflexes including spasticity, and clonus (a series of involuntary rapid muscle contractions) Such signs are collectively termed the "upper motor neuron syndrome".
Muscle paresis or paralysis; Fibrillations; Fasciculations – caused by increased receptor concentration on muscles to compensate for lack of innervation. Hypotonia or atonia – Tone is not velocity dependent. Hyporeflexia - Along with deep reflexes even cutaneous reflexes are also decreased or absent.
A standout feature of cantaloupe is its high vitamin A content, says registered dietitian Samantha Cassetty. One cup provides 40% of the daily recommended intake, primarily in the form of beta ...
CMD with brain-eye, also called muscle-eye-brain disease, [19] is a rare form of congenital muscular dystrophy (autosomal recessive disorder) causing a lack of normal muscle tone which can delay walking due to being weak, also paralysis of eye muscles and intellectual disability which affects an individual's way of processing information. [19]