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Ganciclovir is commonly associated with a range of serious haematological adverse effects. Common adverse drug reactions (≥1% of patients) include: granulocytopenia, neutropenia, anaemia, thrombocytopenia, fever, nausea, vomiting, dyspepsia, diarrhea, abdominal pain, flatulence, anorexia, raised liver enzymes, headache, confusion, hallucination, seizures, pain and phlebitis at injection site ...
Aciclovir topical cream is commonly associated (≥1% of patients) with dry or flaking skin or transient stinging/burning sensations. Infrequent adverse effects include erythema or itch. [ 15 ] When applied to the eye, aciclovir is commonly associated (≥1% of patients) with transient mild stinging.
Human cellular kinases further phosphorylate the molecule to create ganciclovir diphosphate, then ganciclovir triphosphate. [9] These kinases are present in 10-fold greater concentrations in CMV or herpes simplex virus (HSV) -infected cells compared to uninfected human cells, allowing ganciclovir triphosphate to concentrate in infected cells.