Search results
Results From The WOW.Com Content Network
Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT 4 receptor agonist and indirectly as a parasympathomimetic .
Mosapride is a gastroprokinetic agent that acts as a selective 5HT 4 agonist.The major active metabolite of mosapride, known as M1, additionally acts as a 5HT 3 antagonist, [1] which accelerates emptying throughout the whole of the gastrointestinal tract in humans, [2] and is used for the treatment of gastritis, gastroesophageal reflux disease, functional dyspepsia [3] and irritable bowel ...
When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds ...
Certain prokinetic drugs such as cisapride, renzapride and metoclopramide, although not 5-HT 3 antagonists proper, possess some weak antagonist effect at the 5-HT 3 receptor. Galanolactone , a diterpenoid found in ginger , is a 5-HT 3 antagonist and is believed to at least partially mediate the anti-emetic activity of this plant.
Moreover, itopride has no affinity for the 5-HT 4 receptors, unlike other benzamides such as cisapride and mosapride, which are 5-HT 4 agonists. The affinity of cisapride for 5-HT 4 receptors in the heart has been implicated in the undesirable cardiac effects of cisapride itself. [medical citation needed]
Drug interactions [ edit ] The drug inhibits P450 and enhances the effects of terfenadine , astemizole , indinavir , midazolam , calcium channel blockers , warfarin , cisapride and ciclosporin .
The most common side effect seen is constipation (2–3%). Less commonly reported side effects (<0.5%) include flatulence, headache, hypophosphatemia, xerostomia (dry mouth), and bezoar formation. [24] [25] [26] Use of this drug is not recommended for people with chronic kidney failure, as it might cause aluminium accumulation and toxicity.
This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.