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  2. Pregnenolone - Wikipedia

    en.wikipedia.org/wiki/Pregnenolone

    The critical enzyme step is two-fold using a 3β-hydroxysteroid dehydrogenase and a Δ 5-4 isomerase. The latter transfers the double bond from C5 to C4 on the A ring. Progesterone is the entry into the Δ 4 pathway, resulting in production of 17α-hydroxyprogesterone and androstenedione , precursor to testosterone and estrone .

  3. Prednisolone - Wikipedia

    en.wikipedia.org/wiki/Prednisolone

    Common side effects with short-term use include nausea, difficulty concentrating, insomnia, increased appetite, and fatigue. [5] More severe side effects include psychiatric problems, which may occur in about 5% of people. [9] Common side effects with long-term use include bone loss, weakness, yeast infections, and easy bruising. [6]

  4. Myasthenia gravis - Wikipedia

    en.wikipedia.org/wiki/Myasthenia_gravis

    It most commonly affects women under 40 and people from 50 to 70 years old of either sex, but it has been known to occur at any age. Younger people rarely have thymoma. Prevalence in the United States is estimated at between 0.5 and 20.4 cases per 100,000, with an estimated 60,000 Americans affected.

  5. Prednisone - Wikipedia

    en.wikipedia.org/wiki/Prednisone

    This weaning process may be over a few days if the course of prednisone is short but may take weeks or months [33] if the patient had been on long-term treatment. Abrupt withdrawal may lead to an Addisonian crisis. For those on chronic therapy, alternate-day dosing may preserve adrenal function and thereby reduce side effects. [34]

  6. Women of Mayo Clinic - Wikipedia

    en.wikipedia.org/wiki/Women_of_Mayo_Clinic

    These women did amazing things, and it makes me realize I can, too." the young woman told the clinic. [16] MedCity Beat said, "These stories of more than 40 incredible women have now been artfully recounted by local writer and teacher Virginia Wright-Peterson in her new book, Women of Mayo Clinic: The Founding Generation." [17]

  7. Glutamate decarboxylase - Wikipedia

    en.wikipedia.org/wiki/Glutamate_decarboxylase

    The enzyme plays a major role in conferring acid resistance and allows bacteria to temporarily survive in highly acidic environments (pH < 2.5) like the stomach. [57] This is done by GAD decarboxylating glutamate to GABA, which requires H+ to be uptaken as a reactant and raises the pH inside the bacteria.

  8. New RSV vaccines are now available to help prevent serious infection in people over 60. Doctors explain the RSV vaccine and its side effects in older adults.

  9. 21-Hydroxylase - Wikipedia

    en.wikipedia.org/wiki/21-Hydroxylase

    This location is on a side chain of the D ring. The enzyme is a member of the cytochrome P450 superfamily of monooxygenase enzymes. The cytochrome P450 enzymes catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. Steroid 21-hydroxylase is essential for the biosynthesis of cortisol and ...