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Brown adipose tissue (BAT) or brown fat makes up the adipose organ together with white adipose tissue (or white fat). [1] Brown adipose tissue is found in almost all mammals. Classification of brown fat refers to two distinct cell populations with similar functions.
Adipose tissue is derived from preadipocytes and its formation appears to be controlled in part by the adipose gene. The two types of adipose tissue are white adipose tissue (WAT), which stores energy, and brown adipose tissue (BAT), which generates body heat.
A brown fat cell. Yellow adipose tissue in paraffin. White fat cells contain a single large lipid droplet surrounded by a layer of cytoplasm, and are known as unilocular.. The nucleus is flattened and pushed to the periph
White adipose tissue or white fat is one of the two types of adipose tissue found in mammals. The other kind is brown adipose tissue. White adipose tissue is composed of monolocular adipocytes. In humans, the healthy amount of white adipose tissue varies with age, but composes between 6–25% of body weight in adult men and 14–35% in adult women.
PRDM16 is highly enriched in brown adipose cells as compared to white adipose cells, and plays a role in these thermogenic processes in brown adipose tissue. PRDM16 activates brown fat cell identity and can control the determination of brown adipose fate. A knock-out of PRDM16 in mice shows a loss of brown cell characteristics, showing that ...
Additionally, his work highlighted how the absence of brown adipose tissue may contribute to obesity, [21] and that UCP1-expressing cells that can develop in white adipose depots represent a distinct type of adipocyte, termed "brite" (now "beige") adipocytes, due to their unique gene expression profile compared to classical brown adipocytes.
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Leptin is produced primarily in the adipocytes of white adipose tissue. It also is produced by brown adipose tissue, placenta (syncytiotrophoblasts), ovaries, skeletal muscle, stomach (the lower part of the fundic glands), mammary epithelial cells, bone marrow, [19] gastric chief cells, and P/D1 cells. [99]