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Dapagliflozin is an example of an SGLT-2 inhibitor, it is a competitive, highly selective inhibitor of SGLT. It acts via selective and potent inhibition of SGLT-2, and its activity is based on each patient's underlying blood sugar control and kidney function. The results are decreased kidney reabsorption of glucose, glucosuria effect increases ...
The benefits and side effects of sotagliflozin were evaluated in the two clinical trials. [3] In both trials, participants were randomly assigned to receive either sotagliflozin or placebo by mouth once a day. [3] Neither the participants nor the healthcare providers knew which treatment was being given until after the trial was completed. [3]
GLP-1 analogs resulted in weight loss and had more gastrointestinal side-effects, while in general dipeptidyl peptidase-4 (DPP-4) inhibitors were weight-neutral and are associated with increased risk for infection and headache. Both classes appear to present an alternative to other antidiabetic drugs.
[3] [4] It is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that is taken by mouth. [1] [2] The most common side effects include genital yeast infections, urinary tract infections, and increased urination. [4] Bexagliflozin was approved for medical use in the United States in January 2023. [4] [5]
The most common side effects include fungal infections of the vagina and other infections of the female reproductive system. [4] Ertugliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor [3] [4] and is in the class of drugs known as gliflozins. [5]
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