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Cell damage (also known as cell injury) is a variety of changes of stress that a cell suffers due to external as well as internal environmental changes. Amongst other causes, this can be due to physical, chemical, infectious, biological, nutritional or immunological factors. Cell damage can be reversible or irreversible.
Mycoplasma is a genus of bacteria that, like the other members of the class Mollicutes, lack a cell wall, and its peptidoglycan, around their cell membrane. [1] The absence of peptidoglycan makes them naturally resistant to antibiotics such as the beta-lactam antibiotics that target cell wall synthesis.
Many microbial toxins promote infection and disease by directly damaging host tissues and by disabling the immune system. Endotoxins most commonly refer to the lipopolysaccharide (LPS) or lipooligosaccharide (LOS) that are in the outer plasma membrane of Gram-negative bacteria.
That is why some infections with gram-negative bacteria can lead to life-threatening septic shock. [3] The outer membrane protects the bacteria from several antibiotics, dyes, and detergents that would normally damage either the inner membrane or the cell wall (made of peptidoglycan).
Intracellular bacteria are bacteria that have the capability to enter and survive within the cells of the host organism. [1] These bacteria include many different pathogens that live in the cytoplasm and nuclei of the host cell's they inhabit. Two examples of intracellular pathogenic bacteria are Mycobacterium tuberculosis and also Toxoplasma ...
Polymorphic outer membrane proteins (Pmp proteins) on the surface of C. trachomatis use tropism to bind specific host cell receptors, which in turn initiates infection. [24] Pmp proteins B, D, and H have been most associated with eliciting a pro-inflammatory response through the release of cytokines.
To infect a host cell, the virus must first inject its own nucleic acid into the cell through the plasma membrane and (if present) the cell wall. The virus does so by either attaching to a receptor on the cell's surface or by simple mechanical force. The binding is due to electrostatic interactions and is influenced by pH and the presence of ions.
Scheme of the complement system. The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. [1]