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Azacitidine is a chemical analogue of the nucleoside cytidine, which is present in DNA and RNA.It is thought to have antineoplastic activity via two mechanisms – at low doses, by inhibiting of DNA methyltransferase, causing hypomethylation of DNA, [16] and at high doses, by its direct cytotoxicity to abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA ...
Mild illnesses in humans include some cases of the common cold (which is also caused by other viruses, predominantly rhinoviruses), [1] [2] while more lethal varieties can cause SARS, MERS and COVID-19. [3] [4] As of 2021, 45 species are registered as coronaviruses, [5] whilst 11 diseases have been identified, as listed below.
While COVID-19 refers to the disease and SARS-CoV-2 refers to the virus which causes it, referring to the "COVID-19 virus" has been accepted. [9] [25] [29] Reference to SARS-CoV-2 as "the coronavirus" has become somewhat accepted despite such use implying that there is only one coronavirus species. Similarly, use of "COVID" for the disease (if ...
New COVID-19 variants continue to pop up. Experts explain how many COVID variants there are, important subvariants, and the evolution of SARS-CoV-2 virus. ... the SARS-Co-V-2 virus (which causes ...
Dozens of captive animal species have been found infected or proven able to be experimentally infected with SARS-CoV-2, the virus that causes COVID-19. The virus has also been found in over a dozen wild animal species. Most animal species that can get the virus have not been proven to be able to spread it back to humans. The Centers for Disease ...
A COVID-19 vaccine is intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes coronavirus disease 2019 . Prior to the COVID-19 pandemic, an established body of knowledge existed about the structure and function of coronaviruses causing diseases like severe acute ...
Nicotinamide (a form of vitamin B 3) is a potent inhibitor of proinflammatory cytokines. [8] [9] Low blood plasma levels of trigonelline (one of the metabolites of vitamin B3) have been suggested for the prognosis of SARS-CoV-2 death (which is thought to be due to the inflammatory phase and cytokine storm).
The name alphacoronavirus is derived from Ancient Greek ἄλφα (álpha, "the first letter of the Greek alphabet"), and κορώνη (korṓnē, "garland, wreath"), meaning crown, which describes the appearance of the surface projections seen under electron microscopy that resemble a solar corona.