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Dihydrotestosterone (DHT), a metabolite of testosterone, is a critical mediator of prostatic growth. DHT is synthesized in the prostate from circulating testosterone by the action of the enzyme 5α-reductase, type 2. DHT can act in an autocrine fashion on the stromal cells or in paracrine fashion by diffusing into nearby epithelial cells.
High DHT levels cause the hair follicles — the tiny organs throughout your scalp from which your hair grows — to shrink, leading to baldness. Finasteride belongs to a group of medications ...
DHT and a Thinning Hairline. In some men, DHT can bind to receptors in the scalp and cause hair follicles to miniaturize, or shrink.Over time, this process stops the hair follicles from producing ...
By blocking the conversion of testosterone to DHT, finasteride treatment drastically reduces DHT levels in the body. Research has shown that finasteride cuts DHT levels in the prostate by upwards ...
Circulating DHT levels in eugonadal men are about 7- to 10-fold lower than those of testosterone, and plasma levels of testosterone and DHT are highly correlated (correlation coefficient of 0.7). [5] [7] In contrast to the circulation however, levels of DHT in the prostate gland are approximately 5- to 10-fold higher than those of testosterone. [7]
Treatment of men with very high-dosage DHT (a non-aromatizable androgen), which resulted in an increase in DHT levels by approximately 10-fold and complete suppression of testosterone and estradiol levels, showed that none of the measures of sexual function were significantly changed with the exception of a mild but significant decrease in ...
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