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Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene. [5] [6] The protein encoded by this gene is a proinflammatory cytokine. Many cell types, both hematopoietic cells and non-hematopoietic cells, have the potential to
The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene. [5] IL18R1 is also known as CDw218a (cluster of differentiation w218a). The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family.
16174 Ensembl ENSG00000115607 ENSMUSG00000026068 UniProt O95256 Q9Z2B1 RefSeq (mRNA) NM_003853 NM_010553 RefSeq (protein) NP_003844 NP_034683 Location (UCSC) Chr 2: 102.42 – 102.45 Mb Chr 1: 40.55 – 40.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is a human gene ...
In this way, IL-1β, IL-1α, IL-36α, IL-36β, IL-36γ, IL-36RA, IL-37, IL-38, and IL-1RA are very likely ancestral family members sharing a common lineage. [9] However, IL-18 and IL-33 are on different chromosomes and there is insufficient sequence or chromosomal anatomy evidence to suggest they share common ancestry with the other IL-1 ...
Caspase-1 Zymogen. Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides.
Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene. [5] [6] The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production.
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