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  2. Methylenetetrahydrofolate reductase deficiency - Wikipedia

    en.wikipedia.org/wiki/Methylenetetrahydrofolate...

    Methylenetetrahydrofolate reductase deficiency is the most common genetic cause of elevated serum levels of homocysteine (hyperhomocysteinemia). It is caused by genetic defects in MTHFR, which is an important enzyme in the methyl cycle. [1] Common variants of MTHFR deficiency are asymptomatic and have only minor effects on disease risk. [2]

  3. Methylenetetrahydrofolate reductase - Wikipedia

    en.wikipedia.org/wiki/Methylenetetrahydrofolate...

    Methylenetetrahydrofolate reductase (MTHFR) is the rate-limiting enzyme in the methyl cycle, and it is encoded by the MTHFR gene. [5] Methylenetetrahydrofolate reductase catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate , a cosubstrate for homocysteine remethylation to methionine .

  4. 5,10-Methylenetetrahydrofolate - Wikipedia

    en.wikipedia.org/wiki/5,10-Methylenetetrahydrofolate

    5,10-Methylenetetrahydrofolate (N5,N10-Methylenetetrahydrofolate; 5,10-CH 2-THF) is cofactor in several biochemical reactions. It exists in nature as the diastereoisomer [6R]-5,10-methylene-THF. As an intermediate in one-carbon metabolism, 5,10-CH 2 -THF converts to 5-methyltetrahydrofolate , 5-formyltetrahydrofolate , and methenyltetrahydrofolate.

  5. 5,10-methenyltetrahydrofolate synthetase deficiency - Wikipedia

    en.wikipedia.org/wiki/5,10-methenyltetrahydrofo...

    5,10-Methenyltetrahydrofolate synthetase deficiency (MTHFS deficiency) is a rare neurodevelopmental disorder caused by mutations affecting the MTHFS gene, which encodes the enzyme 5,10-Methenyltetrahydrofolate synthetase. [2] The disease starts at birth or in early infancy and presents with microcephaly, short stature, and developmental delay.

  6. 5,10-Methenyltetrahydrofolate - Wikipedia

    en.wikipedia.org/wiki/5,10-methenyltetrahydrofolate

    5,10-Methenyltetrahydrofolate (5,10-CH=THF) is a form of tetrahydrofolate that is an intermediate in metabolism. 5,10-CH=THF is a coenzyme that accepts and donates methenyl (CH=) groups. It is produced from 5,10-methylenetetrahydrofolate by either a NAD+ dependent methylenetetrahydrofolate dehydrogenase , or a NADP+ dependent dehydrogenase . [ 1 ]

  7. Methylenetetrahydrofolate—tRNA-(uracil-5-)-methyltransferase

    en.wikipedia.org/wiki/Methylenetetrahydrofolate...

    The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, tRNA containing uridine at position 54, and FADH2, whereas its 3 products are tetrahydrofolate, tRNA containing ribothymidine at position 54, and FAD. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases.

  8. Tetrahydrofolic acid - Wikipedia

    en.wikipedia.org/wiki/Tetrahydrofolic_acid

    It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase. Many bacteria produce tetrahydrofolic acid via dihydropteroate . [ citation needed ] Humans lack the enzymes to do this, thus molecules that shut down these enzymes are effective antibacterial compounds.

  9. MTHFD1 - Wikipedia

    en.wikipedia.org/wiki/MTHFD1

    Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 (MTHFD1) is a gene located in humans on chromosome 14 [4] that encodes a protein, C-1-tetrahydrofolate synthase, cytoplasmic also known as C1-THF synthase, with three distinct enzymatic activities.