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Attacks of skin redness and burning sensation or pain in one or both external ears are the only common symptoms. [1] Pain is often most pronounced at the ear lobe, and sometimes radiates to the jawbone and cheek. [1] The pain is normally mild, but has occasionally been described as severe. [1]
Frank's sign is a diagonal crease in the ear lobe extending from the tragus across the lobule to the rear edge of the auricle. [1] The sign is named after Sanders T. Frank. [1] It has been hypothesised that Frank's sign is indicative of cardiovascular disease [2] [3] and/or diabetes. [4]
The blood reaching the extremities is not oxygen-rich and when viewed through the skin a combination of factors can lead to the appearance of a blue color. All factors contributing to central cyanosis can also cause peripheral symptoms to appear, but peripheral cyanosis can be observed in the absence of heart or lung failures. [5]
The primary causes include post-cataract surgery, certain medications, and, less commonly, neurological or ophthalmological conditions. Post-cataract surgery is a common cause, as replacing the natural lens with a synthetic one increases exposure to blue light, leading to temporary blue-tinted vision. This effect usually resolves as the eye adapts.
The very term "acrocyanosis" is often applied inappropriately in cases when blue discoloration of the hands, feet, or parts of the face is noted. [1] The principal (primary) form of acrocyanosis is that of a benign cosmetic condition, [ 2 ] sometimes caused by a relatively benign neurohormonal disorder. [ 3 ]
Thickened earlobes-conductive deafness syndrome, also known as Escher-Hirt syndrome, or Schweitzer Kemink Graham syndrome, [1] is a rare genetic disorder which is characterized by ear and jaw abnormalities associated with progressive hearing loss. [2] Two families worldwide have been described with the disorder. [3]
Alopecia occurs for various reasons, including genetics, autoimmune disorders where the immune system attacks hair follicles, hormonal changes, medical treatments like chemotherapy, or other factors.
The idea that acetaldehyde is the cause of the flush is also shown by the clinical use of disulfiram (Antabuse), which blocks the removal of acetaldehyde from the body via ALDH inhibition. The high acetaldehyde concentrations described share similarity to symptoms of the flush (flushing of the skin, accelerated heart rate, shortness of breath ...