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A heart attack occurs suddenly when an atherosclerotic plaque in one of the arteries to your heart ruptures. It can cause symptoms such as: ... cause cholesterol and other substances to collect ...
In people over the age of 70, statins decrease the risk of cardiovascular disease but only in those with a history of heavy cholesterol blockage in their arteries. [25] Most evidence suggests that statins are also effective in preventing heart disease in those with high cholesterol but no history of heart disease.
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
Statins with shorter half-lives are more effective when taken in the evening, so their peak effect occurs when the body's natural cholesterol production is at its highest. A recent meta-analysis suggested that statins with longer half-lives, including atorvastatin, may also be more effective at lowering LDL cholesterol if taken in the evening. [40]
Impact of statins on cholesterol, heart disease risk Cheng-Han Chen, MD , of Saddleback Medical Center, CA, not involved in the study, explained that cholesterol in the body comes from two sources.
Atherosclerosis [a] is a pattern of the disease arteriosclerosis, [8] characterized by development of abnormalities called lesions in walls of arteries.This is a chronic inflammatory disease involving many different cell types and is driven by elevated levels of cholesterol in the blood. [9]