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Imidazole is a planar 5-membered ring, that exists in two equivalent tautomeric forms because hydrogen can be bound to one or another nitrogen atom. Imidazole is a highly polar compound, as evidenced by its electric dipole moment of 3.67 D, [12] and is highly soluble in water.
It is used for ring worm of the body, groin (jock itch), and feet (athlete's foot). [2] It is applied to the skin or vagina as a cream or ointment. [2] [3] Common side effects include itchiness or irritation of the area in which it was applied. [2] Use in pregnancy is believed to be safe for the baby. [4] Miconazole is in the imidazole family ...
In general NSAIs have azole ring system like imidazole and triazole attached to planar aromatic structures. Heterocyclic nitrogen atom is an important factor for NSAIs structure-activity relationship as it interacts with heme iron of the P450 enzymes which inhibit hydroxylation reactions for aromatization. [16]
2-Imidazoline (Preferred IUPAC name: 4,5-dihydro-1H-imidazole) is one of three isomers of the nitrogen-containing heterocycle imidazoline, with the formula C 3 H 6 N 2.The 2-imidazolines are the most common imidazolines commercially, as the ring exists in some natural products and some pharmaceuticals.
The numbering of ring atoms in azoles starts with the heteroatom that is not part of a double bond, and then proceeds towards the other heteroatom. Imidazole and other five-membered aromatic heterocyclic systems with two nitrogens are extremely common in nature and form the core of many biomolecules, such as histidine.
Butoconazole (trade names Gynazole-1, Mycelex-3) is an imidazole antifungal used in gynecology. It is administered as a vaginal cream. It is administered as a vaginal cream. [ 1 ] [ 2 ]
Imidazothiazoles are a class of chemical compounds containing a bicyclic heterocycle (a double ring system) consisting of an imidazole ring fused to a thiazole ring. [1] The structure contains three non-carbon or heteroatoms: two nitrogen atoms and one sulfur atom.
In nature, imidazole alkaloids are found both as secondary plant compounds and as byproducts of histidine metabolism in marine organisms. One well-known imidazole alkaloid is pilocarpine , which is present in the leaves of Paraguay jaborandi .