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The importance of tobacco mosaic virus in the history of viruses cannot be overstated. It was the first virus to be discovered, and the first to be crystallised and its structure shown in detail. The first X-ray diffraction pictures of the crystallised virus were obtained by Bernal and Fankuchen in 1941.
Oldstone's research predominantly focused on lymphocytic choriomeningitis virus (LCMV), an arenavirus of mice which infects mouse cells without killing them. If infected as an adult, LCMV is usually cleared rapidly by the immune system (acute infection), but in mice infected congenitally , the virus can persist in the long term without causing ...
They named the virus as "mouse hepatitis virus (MHV)." [18] Gledhill called the experiments on the highly infectious nature of the virus as a "bizarre discovery". [19] In 1959, John A. Morris at the National Institutes of Health, Bethesda, discovered a new mouse virus, which he named H747, from samples in Japan. When he compared the virus with ...
Later in 1954, Fukumi and his colleagues at the Japan National Institute of Health put forward an alternative explanation for the origin of the virus. It was suggested that the mice used to passage the virus were infected with the mouse virus. Thus, mouse virus was later transferred to embryonated eggs, isolated and finally named the Sendai ...
SARS usually does not make mice particularly sick, however, after the virus had undergone serial passage in the mice, it had become lethal. [ 13 ] Changing the virulence of SARS in this way was important, because without a virulent form of SARS to infect laboratory animals, scientists would have been unable to test the effects of SARS in an ...
Minute virus of mice (MVM) is the exemplar virus of the species Rodent protoparvovirus 1, in the genus Protoparvovirus [1] of the Parvoviridae family of viruses. [2] MVM exists in multiple variant forms including MVMp, which is the prototype strain that infects cells of fibroblast origin, while MVMi, the immunosuppressive strain, infects T lymphocytes. [3]
Sin Nombre virus remains the most common cause of HPS in North America. [6] In its rodent host, it causes a chronic and seemingly asymptomatic infection. [24] Sin Nombre virus is primarily associated with one species of deer mouse, and other hantaviruses discovered in North America follow the same pattern, each with their own natural reservoir. [8]
Murine polyomavirus (also known as mouse polyomavirus, Polyomavirus muris, or Mus musculus polyomavirus 1, and in older literature as SE polyoma or parotid tumor virus; abbreviated MPyV) is an unenveloped double-stranded DNA virus of the polyomavirus family. The first member of the family discovered, it was originally identified by accident in ...