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Fmoc-Oxyma-Synthese. or the coupling reagent COMU which is readily soluble as a dimethylmorpholine-uronium salt and which, like Oxyma, is superior to the standard additive HOBt for the suppression of racemization and acylation efficiency and is comparable to HOAt without presenting an explosion risk such as the benzotriazoles. [5]
Amide coupling is one of the most common reactions in organic chemistry and DMTMM is one reagent used for that reaction. The mechanism of DMTMM coupling is similar to other common amide coupling reactions involving activated carboxylic acids. [1] Its precursor, 2-chloro-4,6,-dimethoxy-1,3,5-triazine (CDMT), has also been used for amide coupling.
Deprotonation of the Seyferth–Gilbert reagent A gives an anion B, which reacts with the ketone to form the oxaphosphetane D. Elimination of dimethylphosphate E gives the vinyl diazo-intermediate Fa and Fb. The generation of nitrogen gas gives a vinyl carbene G, which via a 1,2-migration forms the desired alkyne H.
COMU can refer to: . Çomu, İskilip; Çanakkale Onsekiz Mart University; COMU, (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate.
This reductive coupling can be viewed as involving two steps. First is the formation of a pinacolate (1,2- diolate ) complex, a step which is equivalent to the pinacol coupling reaction . The second step is the deoxygenation of the pinacolate, which yields the alkene , this second step exploits the oxophilicity of titanium.
N,N′-Dicyclohexylcarbodiimide (DCC or DCCD) [1] is an organic compound with the chemical formula (C 6 H 11 N) 2 C. It is a waxy white solid with a sweet odor. Its primary use is to couple amino acids during artificial peptide synthesis.
The Hiyama–Denmark coupling is the modification of the Hiyama coupling that does not require a fluoride additive to utilize organosilanols and organic halides as coupling partners. The general reaction scheme is shown below, showcasing the utilization of a Brønsted base as the activating agent as opposed to fluoride, phosphine ligands are ...
Collins reagent; Combes quinoline synthesis; Conia reaction; Conrad–Limpach synthesis; Cook–Heilbron thiazole synthesis; Cope elimination; Cope rearrangement [24] Corey reagent; Corey–Bakshi–Shibata reduction; Corey–Fuchs reaction; Corey–Gilman–Ganem oxidation; Corey–Kim oxidation; Corey-Nicolaou macrolactonization