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A 2017 review of research literature published in the journal Current Psychiatry Reports notes that it’s common for antidepressants to affect sleep (though it didn’t mention sertraline by name).
Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [10] used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder. [11]
For example, a large-scale systematic review published in the journal Obesity Reviews in 2019 found that most studies of antidepressants and changes in body mass show an average weight increase of ...
Sertraline is the second most potent inhibitor of 5-HT re-uptake which has two very interesting characteristics that distinguish it i.e. sertraline's (1) inhibiting effect on DAT and NET and (2) the binding to sigma-1 (σ 1) receptor in CNS. [18]
Fredrik Hieronymus et al. criticized the review as inaccurate and misleading. [15] In 2018, a systematic review and network meta-analysis comparing the efficacy and acceptability of 21 antidepressant drugs showed escitalopram to be one of the most effective.
Common SSRIs include Prozac (fluoxetine), Zoloft (sertraline) and Lexapro (escitalopram). Effectiveness and side effect rates can vary between SSRIs. Effectiveness and side effect rates can vary ...