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Granulomatous amoebic encephalitis (GAE) [2] is a rare, often fatal, subacute-to-chronic central nervous system disease caused by certain species of free-living amoebae [3] of the genera Acanthamoeba, Balamuthia and Sappinia.
Balamuthia mandrillaris is a free-living amoeba that causes the rare but deadly neurological condition granulomatous amoebic encephalitis (GAE). [1] B. mandrillaris is a soil-dwelling amoeba and was first discovered in 1986 in the brain of a mandrill that died in the San Diego Wild Animal Park.
The Balamuthia amoebae can then travel to the brain through the bloodstream and cause GAE. GAE is a very rare disease that is usually fatal. [2] Scientists at the Centers for Disease Control and Prevention (CDC) first discovered Balamuthia mandrillaris in 1986. The amoeba was found in the brain of a dead mandrill.
Free-living amoebae (or "FLA") [1] are a group of protozoa that are important causes of infectious disease in humans and animals.. Naegleria fowleri is often included in the group "free-living amoebae", [2] [3] and this species causes a usually fatal condition traditionally called primary amoebic meningoencephalitis (PAM).
Naegleriasis, also known as primary amoebic meningoencephalitis (PAM), is an almost invariably fatal infection of the brain by the free-living protozoan Naegleria fowleri. Symptoms include headache , fever , nausea , vomiting , a stiff neck , confusion , hallucinations and seizures . [ 6 ]
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Granulomatous amoebic encephalitis (GAE) is caused by amoebic infection of the central nervous system (CNS). It is characterized by neurological symptoms including headache, seizures, and mental-status abnormalities. [1] These worsen progressively over weeks to months, leading to death in most patients. [1]