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Salicylic acid is an organic compound with the formula HOC 6 H 4 COOH. [3] A colorless (or white), bitter-tasting solid, it is a precursor to and a metabolite of acetylsalicylic acid (aspirin). [3]
The original ointment contains 3% salicylic acid and 6% benzoic acid in a suitable base, such as lanolin or petrolatum. [2] [3] Alternatively, a short-chain alcohol or fatty alcohol can be used as the base. [4]
In addition to other formulations, ciclopirox is used in lacquers for topical treatment of onychomycosis (fungal infections of the nails). A meta-analysis of the six trials of nail infections available in 2009 concluded that they provided evidence that topical ciclopirox had poor cure rates, and that amorolfine might be substantially more effective, but more research was required.
Aspirin is readily broken down in the body to salicylic acid, which itself has anti-inflammatory, antipyretic, and analgesic effects. In 2012, salicylic acid was found to activate AMP-activated protein kinase, which has been suggested as a possible explanation for some of the effects of both salicylic acid and aspirin.
Some toners contain active ingredients and target particular skin types, such as tea tree oil, salicylic acid, or glycolic acid. Hyperpigmentation treatment: Kojic acid soap, cream, or powder, and Arbutin (a b-D-glucopyranoside derivative of hydroquinone) serum or cream help get rid of hyperpigmentation spots of the skin. [25]
The combination was first introduced as the name Trigesic, as the formula of 125 mg paracetamol, 230 mg aspirin, and 30 mg caffeine, in July 1950 by Squibb, which is now Bristol Myers Squibb, but was recalled in the following year due to several reports that the drug might cause blood dyscrasia. [5]