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Δ-10-Tetrahydrocannabinol (Delta-10-THC, Δ 10-THC, alternatively numbered as Δ 2-THC) is a positional isomer of tetrahydrocannabinol, discovered in the 1980s.Two epimers have been reported in the literature, with the 9-methyl group in either the (R) or (S) conformation; of these, the (R) epimer appears to be the more active isomer as well as the double bond in the 10th position instead of ...
Cannabinoids (/ k ə ˈ n æ b ə n ɔɪ d z ˌ ˈ k æ n ə b ə n ɔɪ d z /) are compounds found in the cannabis plant or synthetic compounds that can interact with the endocannabinoid system. [1] [2] The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (Delta-9-THC), the primary intoxicating compound in cannabis.
Δ-8-Tetrahydrocannabinol, which can be converted to THC by addition of HCl followed by dehydrochlorination. [31] [26] [32] Treatment of the purified Δ8 -THC under Lucas' reagent gives the chloro compound. Following treatment with potassium tert-amylate, the desired (-)-6a,10 a-trans-Δ9 -tetrahydrocannabinol is yeilded.
Tetrahydrocannabinol (THC) is the primary psychoactive component of the Cannabis plant. Delta-9-tetrahydrocannabinol (Δ 9-THC, THC) and delta-8-tetrahydrocannabinol (Δ 8-THC), through intracellular CB 1 activation, induce anandamide and 2-arachidonoylglycerol synthesis produced naturally in the body and brain [citation needed] [dubious ...
Tetrahydrocannabinol (THC) is a cannabinoid found in cannabis. [9] It is the principal psychoactive constituent of cannabis and one of at least 113 total cannabinoids identified on the plant. Although the chemical formula for THC (C 21 H 30 O 2 ) describes multiple isomers , [ 10 ] the term THC usually refers to the delta-9-THC isomer with ...
Although CBN shares the same mechanism of action as other phytocannabinoids (e.g., Delta-9-tetrahydrocannabinol, Δ 9-THC), it has a lower affinity for CB 1 receptors, meaning that much higher doses of CBN are required in order to experience effects, such as mild sedation.
The two cannabinoids usually produced in greatest abundance are cannabidiol (CBD) and/or Δ 9-tetrahydrocannabinol (THC), but only THC is psychoactive. [55] Since the early 1970s, Cannabis plants have been categorized by their chemical phenotype or "chemotype", based on the overall amount of THC produced, and on the ratio of THC to CBD. [56]
cis-Delta-9-Tetrahydrocannabinol ((-)-cis-Δ 9-THC) is an isomer of tetrahydrocannabinol found in the Cannabis plant but in lower quantities than the more well-known trans isomer. It has similar psychoactive effects to trans -Δ 9 -THC in tests on mice, but with only around 1/5th the potency.