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  2. Sonidegib - Wikipedia

    en.wikipedia.org/wiki/Sonidegib

    Sonidegib , sold under the brand name Odomzo, is a medication used to treat cancer. [1] Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened ...

  3. Hedgehog pathway inhibitor - Wikipedia

    en.wikipedia.org/wiki/Hedgehog_pathway_inhibitor

    Sonidegib was created by Novartis. It is a SMO antagonist that can induce arrest of cell division and promote apoptosis in cancer cells. [ 14 ] Sonidegib has been effective in limiting the invasive potential of multiple cancer types including glioblastoma , [ 38 ] prostate cancer , [ 39 ] and renal cell carcinoma . [ 40 ]

  4. Glasdegib - Wikipedia

    en.wikipedia.org/wiki/Glasdegib

    Glasdegib was approved for medical use in the United States in December 2018. [5] [6] [9] [10] [11]FDA approval was based on a multicenter, open-label, randomized study (BRIGHT AML 1003, NCT01546038) that included 115 subjects with newly-diagnosed AML who met at least one of the following criteria: a) age 75 years or older, b) severe cardiac disease, c) baseline Eastern Cooperative Oncology ...

  5. FDA approves new pain medication as an alternative to opioids ...

    www.aol.com/news/fda-approves-pain-medication...

    The FDA on Thursday approved a new class of pain medication that provides an alternative to opioids. It will be sold under the brand name Journavx.

  6. Here's how much U.S. car prices could rise if Trump tariffs ...

    www.aol.com/heres-much-u-car-prices-125913491.html

    The average $25,000 price of a car imported from Mexico or Canada could jump $6,250 if the tariffs take effect, according to an analysis by S&P Global Mobility. The automotive research firm ...

  7. How much are Super Bowl tickets? Prices dropping for Chiefs ...

    www.aol.com/much-super-bowl-tickets-prices...

    Last year, the average price was around $9,365 on the secondary market the day before the game, according to TickPick. Get your Super Bowl 59 tickets with StubHub Super Bowl 59 ticket prices

  8. Hedgehog signaling pathway - Wikipedia

    en.wikipedia.org/wiki/Hedgehog_signaling_pathway

    Several hedgehog signaling pathway inhibitors are available for cancer treatment, such as vismodegib and sonidegib. These drugs are regarded as promising cancer therapies, especially for patients with refractory/advanced cancers. SMO inhibitors represent a potential treatment for some types of cancers.

  9. These prices could climb within days if Trump slaps tariffs ...

    www.aol.com/prices-could-climb-within-days...

    That seasonal price impact could add another 30 cents per gallon, putting the total increase in gasoline prices at $1 per gallon if the tariffs remain in place at the onset of spring, Fitzgerald said.

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