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In cellular biology, a somatic cell (from Ancient Greek σῶμα (sôma) ' body '), or vegetal cell, is any biological cell forming the body of a multicellular organism other than a gamete, germ cell, gametocyte or undifferentiated stem cell. [1] Somatic cells compose the body of an organism and divide through mitosis.
In cellular biology, the term somatic is derived from the French somatique which comes from Ancient Greek σωματικός (sōmatikós, “bodily”), and σῶμα (sôma, “body”.) [1] [2] is often used to refer to the cells of the body, in contrast to the reproductive cells, which usually give rise to the egg or sperm (or other gametes in other organisms).
Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate damaged tissues. Also known as somatic stem cells (from Greek σωματικóς, meaning of the body), they can be found in juvenile, adult animals, and humans, unlike embryonic stem ...
For example, in mammals, somatic cells make up the internal organs, skin, bones, blood, and connective tissue. [1] In most animals, separation of germ cells from somatic cells (germline development) occurs during early stages of development. Once this segregation has occurred in the embryo, any mutation outside of the germline cells can not be ...
In addition, stem cell are undifferentiated cells which can develop into a specialized cell and are the earliest type of cell in a cell lineage. [2] Due to the differentiation in function, somatic cells are found only in multicellular organisms, as in unicellular ones the purposes of somatic and germ cells are consolidated in one cell.
Somatic hypermutation (or SHM) is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes).A major component of the process of affinity maturation, SHM diversifies B cell receptors used to recognize foreign elements and allows the immune system to adapt its response to new threats during the lifetime of an organism. [1]
Human somatic variations are somatic mutations (mutations that occur in somatic cells) both at early stages of development and in adult cells. These variations can lead either to pathogenic phenotypes or not, even if their function in healthy conditions is not completely clear yet.
Somatic (biology), referring to the cells of the body in contrast to the germ line cells Somatic cell, a non-gametic cell in a multicellular organism; Somatic nervous system, the portion of the vertebrate nervous system which regulates voluntary movements of the body; Somatics, a group of alternative medicine approaches, experiential movement ...