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There are seven STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. [1] STAT proteins contain many different domains, each with a different function, of which the most conserved region is the SH2 domain. [2] The SH2 domain is formed of 2 α-helices and a β-sheet and is formed approximately from residues 575–680.
Once STAT reaches the nucleus, it binds to a consensus DNA-recognition motif called gamma-activated sites (GAS) in the promoter region of cytokine-inducible genes and activates transcription. The STAT protein can be dephosphorylated by nuclear phosphatases , which leads to inactivation of STAT and subsequent transport out of the nucleus by an ...
STAT1 has a key role in many gene expressions that cause survival of the cell, viability or pathogen response. There are two possible transcripts (due to alternative splicing) that encode 2 isoforms of STAT1. [9] [10] STAT1α, the full-length version of the protein, is the main active isoform, responsible for most of the known functions of ...
20849 Ensembl ENSG00000138378 ENSMUSG00000062939 UniProt Q14765 P42228 RefSeq (mRNA) NM_001243835 NM_003151 NM_011487 NM_001308266 RefSeq (protein) NP_001230764 NP_003142 NP_001295195 NP_035617 Location (UCSC) Chr 2: 191.03 – 191.15 Mb Chr 1: 52.03 – 52.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Signal transducer and activator of transcription 4 (STAT4) is a transcription ...
Taking this one stage further, the clue word can hint at the word or words to be abbreviated rather than giving the word itself. For example: "About" for C or CA (for "circa"), or RE. "Say" for EG, used to mean "for example". More obscure clue words of this variety include: "Model" for T, referring to the Model T.
Withholding transcripts. Over 6.6 million students have their transcripts withheld due to unpaid balances, preventing students from transferring or getting job opportunities that require ...
STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT3 is phosphorylated by receptor-associated Janus kinases (JAK), forms homo- or heterodimers, and translocates to the cell nucleus where it acts as a transcription activator.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.