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Adenovirus infection is a contagious viral disease, caused by adenoviruses, commonly resulting in a respiratory tract infection. [ 1 ] [ 9 ] Typical symptoms range from those of a common cold , such as nasal congestion , rhinitis , and cough , to difficulty breathing as in pneumonia . [ 9 ]
The structure of adenovirus. 1 = penton capsomers, 2 = hexon capsomers, and 3= viral genome (linear dsDNA) Adenoviruses are medium-sized (90–100 nm). [ 2 ] The virions are composed of one linear piece of double-stranded DNA inside an icosahedral capsid . 240 hexon proteins make up the bulk of the capsid, while twelve penton bases cap the ...
Adenoviral keratoconjunctivitis, also known as epidemic keratoconjunctivitis, is a contagious eye infection, a type of adenovirus disease caused by adenoviruses. [1] It typically presents as a conjunctivitis with a sudden onset of a painful red eye, watery discharge and feeling that something is in the eye. [3]
Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral fiber glycoproteins to host receptors, which mediates endocytosis.
The example used for the following description is Human adenovirus E, a mastadenovirus with a 36 Kbp genome containing 38 protein-coding genes. [2] While the precise number and identity of genes varies among adenoviruses, the basic principles of genome organization and the functions of most of the genes described in this article are shared ...
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The virus was first called Adenovirus 127 after this strain, before being named Duck adenovirus A. [4] [5] This strain was the first strain of the virus to get a full genome sequence in the GenBank database. [6] The virus was renamed Duck atadenovirus A in 2013. [citation needed]
The vector is a chimpanzee adenovirus modified to avoid its replication. [1] Adenoviruses are effective vectors for inducing and boosting cellular immunity to encoded recombinant antigens. However, the widespread seroprevalence of neutralizing antibodies to common human adenovirus serotypes limits their use. Simian adenoviruses do not suffer ...